After a fracture, patients often continue meds that boost fracture risk

23 Aug, 2016 11:29 am

NEW YORK – Older people who break a bone are often receiving medications that can increase the risk of a fracture – and even after an accident, less than 10 percent of them stop taking those drugs, according to a new study.

“One would expect that a significant health event like a fracture would result in some change in the use of prescription drugs that might have contributed to that event,” said lead author Dr Jeffrey C Munson of the Geisel School of Medicine at Dartmouth in Lebanon, New Hampshire. “In contrast to this expectation, we observed that for the overwhelming majority of patients we studied, a fragility fracture did not lead to any change in medications that have been linked to fracture risk.”

The authors used data on 168,000 Medicare beneficiaries, more than 80 percent of whom were women, on average age 80, who had experienced a hip, shoulder or wrist fracture. They compared these records with retail pharmacy claims to identify which patients had been taking medicines that increase the risk of a fall, decrease bone density or are otherwise tied to an increased risk of fracture.

Fragility fractures are common for the elderly and can lead to hospitalization, pain, and loss of function and independence – particularly hip fractures, which have a high mortality rate, Munson said.

About 75 percent of fracture patients had been taking one of these medications. While seven percent of people stopped taking the medication after their fracture, a similar number started to take a new medication also tied to fracture risk, the authors reported in JAMA Internal Medicine.

“Some drugs affect balance and memory, like the sleeping pills, which can lead to a fall,” said Dr Sarah D Berry of the Institute for Aging Research at Hebrew SeniorLife in Boston, Massachusetts, who coauthored an editorial alongside the results.

Blood pressure medications cause changes in blood pressure that could lead to a fall. Berry said. Other drugs, like prednisone or medications for heartburn, increase bone loss which can lead to a fracture, she told Reuters Health by email.

“Fractures are the leading cause of death from injury and one of the main reasons for nursing home placement in persons over the age of 65,” she said.

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